Trost Lab

Check out our new paper in Molecular and Cellular Proteomics.

Proteomic Analysis Reveals Trilaciclib-Induced Senescence

Great achievement by visiting undergraduate students from Spain!

Well done, everyone involved!

https://www.mcponline.org/article/S1535-9476(24)00068-9/fulltext

Please check out this great review by Amy, Maria and Jose:

Stability-based approaches in chemoproteomics

the pdf can be downloaded here: stability-based-approaches-in-chemoproteomics

please find our latest preprint on comparison of macrophage cell lines here:

https://www.biorxiv.org/content/10.1101/2024.04.09.588684v1

Well done, Jack, Jose and Frances!

 

Huge Congratulations to Frances Sidgwick for successfully defending her thesis on February 9th! Well done Dr Sidgwick!

 

Thanks also to Profs Aneika Leney and Mike Taggart for their examination!

Jack recently successfully defended his PhD thesis.

Congratulations, Dr Gudgeon!

Many thanks to the examiners Dave Boucher and Kevin Marchbank!

A warm welcome to our three new PhD students starting this September!

Meihan is a BBSRC iCASE student and will use highly sensitive mass spectrometry approaches to study ubiquitylation in the eno-lysosomal system.

Mengchun is a GSK-funded student within the MosMed DTP and will develop mass spectrometry approaches to address capability gaps in drug discovery for membrane transporters.

Simran is a Boehringer Ingelheim-funded student within the MosMed DTP and will utilise proteomics approaches in characterising disease models in inflammatory bowel disease and develop novel approaches for drug deconvolution.

We just said goodbye to our fantastic postdocs Maria Dueñas and José Luis Marin Rubio who move to the University of Perth (Australia) and the Memorial Sloan Kettering Cancer Center in New York, respectively!

We are extremely grateful for their amazing work and wish them good luck for the future!

 

Great collaboration with the Cousin Lab in Edinburgh! check the paper out here:

Bonnycastle, K., Dobson, K.L., Blumrich, E.M., Gajbhiye, A., Davenport, E.C., Pronot, M., Steinruecke, M., Trost, M., Gonzalez-Sulser, A., Cousin, M.A., Reversal of cell, circuit and seizure phenotypes in DNM1 epileptic encephalopathy,(2023) Nature Communications Aug 30;14(1):5285. doi: 10.1038/s41467-023-41035-w.

Congratulations to Amy for publishing her first first-author paper “A benchmark of LFQ-DIA against  current TMT-DDA multiplexing approaches for thermal proteome profiling (TPP) using losmapimod in AML. ” in Journal of Proteome Research!